Dr. Shagufta Parveen

Assistant Professor

Manipal Institute of Regenerative Medicine

Qualification: PhD

CURRENT ACADEMIC ROLE & RESPONSIBILITIES

     Assistant Professor  in the Manipal Institute  of Regenerative Medicine at   Manipal Academy of Higher Education. 

SUBJECTS CURRENTLY TEACHING

Subject Semester / Year
Biochemistry I Semester
Developmental Biology I Semester
Molecular Biology I Semester
Molecular Techniques II Semester
Immunology II Semester
Application of Stem Cells III Semester

ACADEMIC QUALIFICATIONS

Degree Specialisation Institute Year of passing
MSc Microbiology Bangalore University 2000

Experience

Institution / Organisation Designation Role Tenure
Manipal Institute of Regenerative Medicine Manipal Academy of Higher Education (MAHE) Assistant Professor Teaching 16+ Years
St Josephs University Lecturer Teaching 7 Months
PESIAS Lecturer Teaching 6+ years

Research Focus:

I am extremely passionate about pluripotent stem cell research. The mere plethora of research that can be conducted with PSCs fascinates me. I have channeled this interest into basic research by using induced PSCs as my principal cellular system. PSCs have inherent potential to transform into a myriad of cell types which I exploit to understand fundamental cellular and molecular mechanisms of early embryonic development, development malformations, cellular shapes and differentiation of cells from one type to another. I am presently working on the following areas regarding human development and disease.

1.      Generation of iPSCs from cells isolated from individuals with developmental disorders like fetal death, neural tube defects and Turners syndrome.

2. Modelling Neural tube defects using organoids.

3. Modelling bicuspid aortic valve using iPSC derived cellular models.

4. Generation of blastoid/ gastruloid models to study implantation failures.

5. Wound healing using mesenchymal cell derived exosomes.

AREAS OF INTEREST, EXPERTISE AND RESEARCH

Area of Interest

Disease modelling and correction in pluripotent stem cells

Area of Expertise

Pluripotent stem cells and reprogramming

Area of Research

Generation of induced pluripotent stem cells

1.     Parveen, S., Panicker, M. M. & Gupta, P. K. Lab resource: Stem cell line:  Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion. Stem Cell Res. 19, 12–16 (2016). https://doi.org/10.1016/j.scr.2016.12.016

2.     Parveen, S. Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells. Stem Cell Res. 27, 15–20 (2018). https://doi.org/10.1016/j.scr.2017.12.008

3.     Parveen, S., Singh, S. P., Panicker, M. M. & Gupta, P. K. Amniotic membrane as novel scaffold for human iPSC-derived cardiomyogenesis. Vitr. Cell. Dev. Biol. - Anim. (2019). https://doi.org/10.1007/s11626-019-00321-y

4.     Shivaraj, A. & Parveen, S. Generation of integration free human iPSC line SORMi002-A from neonatal foreskin fibroblasts. Stem Cell Res. 40, 101534 (2019). https://doi.org/10.1016/j.scr.2019.101534

5.     Nivedha Veerasubramanian, Vaishnavi Karthikeyan, Sridevi Hegde, Anandh Dhanushkodi, Shagufta Parveen. JoVE62240 "Generation of induced pluripotent stem cells from Turner Syndrome (45XO) fetal cells for downstream modelling of associated neurological deficits" Journal of Visualized Experiments JOVE  https://doi.org:10.3791/62240