Laser induced fluorescence (LIF) spectroscopy and pulsed laser Photoacoustic Spectroscopy (PAS) are extremely sensitive techniques for the detection and quantitation of subnanogram quantities of biological compounds. Laser induced fluorescence set up in our laboratory is standardised for oral, cervical and breast cancer detection for optical pathology. The next aim based on laser induced fluorescence spectroscopy study is to extend it for in-vivo measurements and finally to develop a portable in-vivo system for screening different cancers.