Research

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Expertise available in the department for Biological activity screening

Early Research Work

Certain dipheny ether derivatives synthesized were active at 1ppm concentration in the antitubercular screening. Further studies are in progress
Selected Triterpenes have been isolated from plant sources and their anticancer activity potential has been considerably enhanced by structural modifications
Several amino flavones with heterocyclic systems incorporated were synthesized and promising anticancer activity observed with a few compounds
Isolation of new structural classes of natural products and structure elucidation by 1D and 2D NMR from some prigoniaceae numbers
Bio assay guided isolation of benzyl and coumestan derivatives processing significant antitumour and antiprotozoal activity. The novel benzyl molecule was found to be two-fold more potent than the standard drug. Ambrucin HCL on HT -29 cell lines (IC50=2.90µM)
A novel antiprotozoal isoflavanol was adentified from tephoria spp.and was found to be potent against trypanosome brucci rhodansiense, Leishmania donovani and trypanosome cruzi(IC50-3.7,17.2 and 3.3 µg/ml)
Design and synthesis of some of the newer 2-Quinolones with the structural modifications on the ring system established promising antioxidant and antibacterial activity
Some of the newer synthetic flavones and flavanols were synthesized and their structures were established

What we are doing currently?

Compound isolation, characterisation and bioactive studies
Synthetic modification of naturally occurring compounds
Bio isosteric modifications on benzopyrones
Antioxidant, Nitric oxide scavenging activity of newly synthesized compounds.
Drug discovery on antimicrobial, antitubercular, anticancer, anti-inflammatory activity
Isolation and characterisation of natural products with anti allergic activity
Analytical method developments